Nursing considerations for filgrastim

Oncology Nursing Forum Vol. 42, No. 4, July 2015 417 of filgrastim has been reported to be associated with increased incidence of febrile episodes compared to glycosyl-ated filgrastim (Orciuolo et al., 2011). Febrile episodes could be attributed to an impairment of neutrophils during exposure to non-glycosylated lgrastim (Ribeiro et al., 2007).

Nursing Management. There are a couple of nursing management and considerations that nurses have to keep in mind when taking care of a client with leukemia. Radiation and Chemotherapy. These are primarily given to decrease the abnormally high number of white blood cells. Radiation and chemotherapy will …aka. neupogen. class. increase neutrophil production, colony-stimulating factor. actions. increase neutrophil production in bone marrow and enhance phagocytoic and cytotoxic function of existing neutrophils. who does it help. pt. with neutropenia assoc. w/ bacterial and fungal infections. who gets it.Neupogen ® (filgrastim) is a drug that has been used successfully for cancer patients to stimulate the growth of the white blood cells, making patients less vulnerable to infections, it is expected to help patients who have bone marrow damage from very high doses of radiation in much the same way. A person who has received a very high dose of ...Subcutaneous. Do not administer filgrastim in the period 14 d before or 24 h after cytotoxic chemotherapy. Use only one dose per vial; do not reenter the vial. Prior to injection, filgrastim may be allowed to reach room temperature for a maximum of 6 h. Discard any vial left at room temperature for >6 h. Aspirate prior to injection to avoid ...Filgrastim is a medication that is used to stimulate the production of white blood cells in patients undergoing chemotherapy or bone marrow transplantation. As a nurse, it is important to be aware of the nursing considerations for filgrastim in order to provide the best possible care for your patients.Find information on Filgrastim (Granix, Neupogen) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.

of 0.2% (2 mg/mL) to prevent adsorption of filgrastim to glass or plastic administration sets.(24) Compatibility: Dilution in NS may cause precipitation.(3) IV push Not indicated Intermittent infusion Over 15–60 minutes(3,5,12-15) Continuous infusion The total daily dose may be diluted in 10–50 mL D5W and infused continuously over 24 hoursinflammation of your blood vessels --numbness or tingling, skin rash, fever, headache, body aches, night sweats, weight loss, feeling or weak or tired; or. kidney problems --swelling, urinating ...View ATI Pharm - filgrastim.pdf from NUR 336 at Missouri Western State University. ACTIVE LEARNING TEMPLATE: Medication Kourtney Chaney STUDENT NAME_ filgrastim 26 MEDICATION_ REVIEW MODULE ... View Eopetin alfa medication template.png from NURSING 00 at Eastern Suffolk Boces Adul... ALT Medication - Epoetin alpha.pdf. Sierra College. NURSING ...The carcinogenic potential of filgrastim has not been studied. Filgrastim failed to induce bacterial gene mutations in either the presence or absence of a drug metabolizing enzyme system. Filgrastim had no observed effect on the fertility of male or female rats at doses up to 500 mcg/kg. Use In Specific Populations Pregnancy Risk SummaryFurosemide is often prescribed to alleviate symptoms associated with fluid overload, such as shortness of breath, swelling, or fatigue. The desired outcome is a reduction in these symptoms, leading to improved exercise tolerance, enhanced quality of life, and overall symptom relief. 5. Electrolyte Balance.A neutropenic client is receiving filgrastim, a granulocyte colony-stimulating factor (G-CSF) used for stimulating neutrophil production, often after chemotherapy or for mobilizing hematopoietic stem cells for procedures such as a transplant. There are several nursing considerations for this medication:Epoetin Alfa 8/9. If you have questions or concerns, contact your healthcare provider. A member of your care team will answer Monday through Friday from 9 a.m. to 5 p.m. Outside those hours, you can leave a message or talk with another MSK provider. There is always a doctor or nurse on call.

PHYSICAL THERAPY IMPLICATIONS + + + Examination and Evaluation + + Be alert for signs of excessive CNS stimulation, including hyperactivity, restlessness, tremor, or irritability. Report these signs to the physician. Monitor attentiveness and behavior in patients with ADHD. Report any changes in attention and hyperactivity, and document …Information obtained from Kaplan NCLEX-RN Drug Guide Sixth Edition ISBN:978-1-62523-114-7 Learn with flashcards, games, and more — for free.Aldesleukin is administered intravenously, and can be used for treatment of metastatic melanoma or metastatic renal cancer. Immunomodulators: Nursing pharmacology Videos, Flashcards, High Yield Notes, & Practice Questions. Learn and reinforce your understanding of Immunomodulators: Nursing pharmacology.For physicians, there was variability in the choice of chemotherapy regimens that required G-CSF support, the dose of filgrastim prescribed and the number of days prescribed. The majority of physicians reported using 5 (31.6%), 7 (47.4%), or 10 (13.2%) days of therapy. Nearly half of the patients (46.3%) recalled having experienced at least one ...With intravenous use or subcutaneous use: For subcutaneous or intravenous infusion, manufacturer advises give continuously or intermittently in Glucose 5%; for a filgrastim concentration of less than 1 500 000 units/mL (15 micrograms/mL) albumin solution (human albumin solution) is added to produce a final albumin concentration of 2 mg/mL; should …

Sam siesta key parents.

INTRODUCTION. Cytotoxic chemotherapy can cause profound and sometimes prolonged neutropenia, which may result in hospitalization for treatment of fever or cause a potentially fatal infection [].Although profound prolonged neutropenia is most likely in the pre-engraftment phase of hematopoietic cell transplantation (HCT; particularly allogeneic) and in patients undergoing induction therapy for ...Mar 1, 2024 · inflammation of your blood vessels - numbness or tingling, skin rash, fever, headache, body aches, night sweats, weight loss, feeling or weak or tired; or. kidney problems - swelling, urinating less, feeling tired or short of breath. Common Neupogen side effects may include: fever, pain, cough, trouble breathing; Find information on Filgrastim (Granix, Neupogen) in Davis's Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.NARCAN Nasal Spray is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression. ( 1 ) NARCAN Nasal Spray is intended for immediate administration as emergency therapy in settings where opioids may be present.Point of Care - Clinical decision support for Filgrastim. Treatment and management. Indications, Mechanism of Action, Administration, Adverse Effects, Contraindications, Monitoring, Toxicity, Enhancing Healthcare Team Outcomes

Nursing Interventions. Client Education. Matilda Hjaertstroem Filgrastim Therapy 26 Leukopoietic Growth Factors. Leukopoietic growth factors stimulate the bone marrow to increase production of neutrophils. IVboluss continous IVs subcutaneous infusions subcutaneous injection. calculated bymcm/km; IVinfusion ovr 15 -30 min; Duration of therapy ...The active substance in Zarzio, filgrastim, is very similar to a human protein called granulocyte colony stimulating factor (G-CSF). Filgrastim is produced by a method known as 'recombinant DNA technology': it is made by a bacterium that has received a gene (DNA), which makes it able to produce filgrastim.Neupogen ® can be used in adults and children of all ages, including pregnant and nursing women for whom Neupogen ® is deemed clinically appropriate. Neupogen ® should not be taken by people who have known hypersensitivity to filgrastim, peg-filgrastim, or any component of filgrastim such as E. coli -derived proteins.For neutropenia: Adults and children—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 to 10 microgram per kilogram …Filgrastim is a single-lineage growth factor that stimulates the maturation and release of only segmented neutrophils. This drug is not given unless the neutrophil count is dangerously low. The near-normal range of neutrophils indicates effective therapy. Start studying Drugs 15 - filgrastim (Neupogen).Anticoagulant Patient Education Nursing. Anticoagulants are a group of drugs that are used to prevent blood clot formation. Blood clots are clumps of blood products that can form in the blood vessels. These clots can dislodge and travel into the circulation and get stuck in arteries and veins causing serious medical emergencies such as stroke ...Zarxio is a man-made form of a substance produced by the body known as granulocyte colony-stimulating factor (G-CSF). G-CSF stimulates the growth of neutrophils, a type of white blood cell that helps the body fight against infection. Man-made forms of naturally occurring substances are known as biosimilars.PhosLo¬Æ is a phosphate binder indicated for the reduction of serum phosphorus in patients with end stage renal disease. ( 1 ) View Our Nursing Pharmacology Course. References: https://open.fda.gov/. Other Pharm Resources. HYDROXYPROGESTERONE CAPROATE (Makena) Nursing Considerations.

Centers for Medicaid and Medicare Service propose a rule that would kill the ban on mandatory arbitration clauses in nursing home contracts. By clicking "TRY IT", I agree to receiv...

epoetin alpha (Epogen, Procrit) classification. hematopoietic growth factor. epoetin alpha (Epogen, Procrit) side effects. HTN, pure red cell aplasia, seizures if BP & Hct rise rapidly, HA, fever, nausea, diarrhea, edema, BBW: ↑ risk for cardiovascular and thromboembolic events. epoetin alpha (Epogen, Procrit) nursing considerations.Filgrastim is used to prevent or reduce the risk of infections while you are being treated with cancer medicines. This medicine is also used to help the bone marrow recover after a bone marrow transplantation, for a process called peripheral blood progenitor cell collection in cancer patients, and to improve survival in cancer patients who have ...Chlorpheniramine maleate is an antihistamine indicated for symptomatic relief of symptoms associated with perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis. Generic Names & Brand Names chlorpheniramine maleate (klor fen ir‘ a meen) Aller-Chlor; Allergy; Chlo-Amine; Chlor-Trimeton Allergy 4 hr, 8 hr, and 12 hr; …Filgrastim Granulocyte Colony-Stimulating Factor / administration & dosage Granulocyte Colony-Stimulating Factor / therapeutic use* Humans Infant, Newborn Infant, Premature, Diseases / drug therapy* Male Neutropenia / congenital* ...Filgrastim Granulocyte Colony-Stimulating Factor / administration & dosage Granulocyte Colony-Stimulating Factor / therapeutic use* Humans Infant, Newborn Infant, Premature, Diseases / drug therapy* Male Neutropenia / congenital* ...1 INDICATIONS AND USAGE NEUPOGEN is a leukocyte growth factor indicated to Decrease the incidence of infection‚Äö as manifested by febrile neutropenia‚Äö in patients with nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of severe neutropenia with fever ( 1.1 ) Reduce the time to neutrop... General considerations. Filgrastim is a close analog of human granulocyte colony-stimulating factor (G-CSF) that works by stimulating bone marrow production of white blood cells. Commercially available filgrastim therapeutics are currently licensed for use in reducing the duration of post-chemotherapy neutropenia, cyclical neutropenia ... Contraindication. NEUPOGEN ® is contraindicated in patients with a history of serious allergic reactions to human granulocyte colony-stimulating factors (G-CSFs), such as filgrastim or pegfilgrastim; Splenic Rupture. Splenic rupture, including fatal cases, can occur following the administration of NEUPOGEN ®; Evaluate patients who report left …

Esne crossword clue.

Lankybox happy meal.

The specific dosing depends on the indication for use. In the outpatient setting, it is much more common to administer peg-filgrastim (Neulasta). It is administered as a single 6mg subcutaneous injection. Only a single dose per cycle of chemotherapy is necessary. A newer formulation of peg-filgrastim, the Neulasta OnPro is another convenient ...Myelosuppressive Chemotherapy Treatment. Neupogen, Granix, Zarxio, Nivestym. Indicated to decrease infection incidence‚ as manifested by febrile neutropenia‚ in patients with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with a significant incidence of severe neutropenia with feverIntramuscular penicillin G benzathine is indicated in the treatment of infections due to penicillin-G-sensitive microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.FILGRASTIM (NEUPOGEN) Nursing Considerations. DEXRAZOXANE (Dexrazoxane) Nursing Considerations. RIFABUTIN (Mycobutin) Nursing Considerations. View the FULL Outline.Zarxio is a man-made form of a substance produced by the body known as granulocyte colony-stimulating factor (G-CSF). G-CSF stimulates the growth of neutrophils, a type of white blood cell that helps the body fight against infection. Man-made forms of naturally occurring substances are known as biosimilars.Please refer to the other literature in this special edition of Seminars in Oncology Nursing for psychosocial considerations during HCT. ... The nurse will typically administer granulocyte colony stimulating factor (g-CSF) drugs (e.g., tbo-Filgrastim [Granix®]) by subcutaneous injection to shorten the time from neutropenia to …Information obtained from Kaplan NCLEX-RN Drug Guide Sixth Edition ISBN:978-1-62523-114-7 Learn with flashcards, games, and more — for free.A client receiving chemotherapy has a serum neutrophil level of less than 2,300/mm3. The nurse should expect to complete which collaborative and nursing interventions? Select all that apply. a. Administer filgrastim 5 mg/kg/day intravenously. b. Prepare client for administration of whole-blood transfusion. c.There are 530+ nursing pharmacology practice questions in this nursing test bank. Nursing topics include medication administration, dosage calculations, general concepts about nursing pharmacology, cardiovascular drugs, antibiotics and anti-infectives, neurological medications, psychiatric medications, drugs for the respiratory system ...Put the original carton with any unused prefilled syringes back in the refrigerator. Remove the syringe tray from the carton. On a clean, well-lit surface, place the syringe tray at room temperature for 30 minutes before you give an injection. Do not use the prefilled syringe if the carton is damaged.Nursing Implications. Assessment & Drug Effects. Withhold drug and notify physician when serum ferritin level equals or exceeds established guidelines. Stop infusion and notify physician for S&S overdosage or infusing too rapidly: hypotension, edema; headache, dizziness, nausea, vomiting, abdominal pain, joint or muscle pain, and paresthesia. ...While pegfilgrastim—a longer-acting version of filgrastim that requires only a single dose administered subcutaneously once per chemotherapy cycle—is now (by far) the most commonly used CSF prophylactic agent in US clinical practice, filgrastim accounts for a small but important segment of the prophylactic market [14,16]. In the present ... ….

of 0.2% (2 mg/mL) to prevent adsorption of filgrastim to glass or plastic administration sets.(24) Compatibility: Dilution in NS may cause precipitation.(3) IV push Not indicated … The specific dosing depends on the indication for use. In the outpatient setting, it is much more common to administer peg-filgrastim (Neulasta). It is administered as a single 6mg subcutaneous injection. Only a single dose per cycle of chemotherapy is necessary. A newer formulation of peg-filgrastim, the Neulasta OnPro is another convenient ... nursing considerations for pegfilgrastim-hypersensitivity to filgrastim/E.coli-pts with sickle cell-concurrent use of lithium-malignancy with myeloid characteristics-pregnancy-nursing-ARDS-sickle cell crisis-splenic rupture-anaphylaxis-capillary leak syndrome. nursing pre administration assessmentNursing Interventions Client Education Felicia Ahl Filgrastim colony stimulating factors A glycoprotein, filgrastim binds to and stimulates immature neutrophils to divide and differentiate. Also activates mature neutrophils. IV, subcut Simultaneous use with antineoplastics may have adverse effects onAs the incidence of cancer in pregnancy has been increasing in recent decades, more specialists are confronted with a complex oncologic–obstetric decision-making process. With the establishment of (inter)national registries, including the International Network on Cancer, Infertility and Pregnancy, and an increasing number of smaller cohort studies, more …Administration of filgrastim will shorten the length of time of neutropenia in patients with cancer whose bone marrow has been suppressed by antineoplastic drugs or in patients following bone marrow or stem cell transplants. ... What are nursing considerations for administering this drug? (Select all that apply.) a. Monitor intravenous site for ...Monitor ECG constantly. Give 50-100 mg at rate of 25-50 mg/min. One-third to one-half the initial dose may be given after 5 min if needed. Do not exceed 200-300 mg in 1 hr. IV, continuous infusion. Arrhythmia: Give 1-4 mg/min (or 20-50 mcg/kg/min). Titrate the dose down as soon as the cardiac rhythm stabilizes.Drug Name Generic Name : folic acid (folate) Brand Name: Folvite Classification: Folic acid, Vitamin supplement Pregnancy Category A Dosage & Route Available forms : Tablets—0.4, 0.8, 1 mg; injection—5 mg/mL Dosages : Administer orally unless patient has severe intestinal malabsorption. ADULTS Therapeutic dose: Up to 1 mg/day PO, IM, IV, or subcutaneously. Larger doses may be needed in ...Nursing is one of the most rewarding careers around. The role involves assisting doctors care for patients and providing treatment. There are many routes nurses can take, including... Nursing considerations for filgrastim, These are vital nursing interventions done in patients who are taking local anesthetics: Prepare emergency equipment to maintain airway and provide mechanical ventilation if needed. Ensure that patients receiving spinal anesthesia or epidural anesthesia are well hydrated and remain lying down for up to 12 hours after the anesthesia to minimize ..., Nursing Considerations for Hydralazine. Gather the patient's health information. These include past and present medical history specifically the history of heart attack, coronary artery disease, rheumatic heart disease, liver or kidney increase. For a patient with a history or current heart problem, taking Hydralazine may worsen the condition., Search. Log inCart. Filgrastim. December 2, 2022Updated: February 16, 2024Cathy Parkes. Share Share. Link. Close shareCopy link. Filgrastim is a medication used to stimulate the growth of neutrophils in patients with neutropenia. Hint:You fillup on neutrophils with filgrastim., Uses. An antiinflammatory agent in the management of acute and chronic inflammatory diseases, for palliative management of neoplastic diseases, and for control of severe acute and chronic allergic processes. High-dose, short-term therapy: management of acute bronchial asthma, prevention of fat embolism in patient with long-bone fracture., Feb 10, 2024 · Filgrastim is a biosynthetic (recombinant DNA origin) hematopoietic agent that principally affects the proliferation and differentiation of neutrophils within the bone marrow and possibly other sites (e.g., spleen). 2. Filgrastim and tbo-filgrastim are structurally and pharmacologically similar drugs that contain a related drug substance. , Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain. Signs of lung or breathing problems like shortness of breath or other trouble breathing, cough, or fever. Dark urine. Chest pain or pressure or a fast heartbeat . Dizziness or passing out., Before the first granulocyte colony-stimulating factor (G-CSF) filgrastim (Neupogen) was launched in the UK in 1991, little could be done to prevent the neutropenia and potentially life-threatening infection associated with some of the chemotherapy regimens of the day. Barry Hancock, emeritus professor of oncology at the University of Sheffield, recalls that chemotherapy in the 1980s […], These are vital nursing interventions done in patients who are taking antibiotics: Check culture and sensitivity reports to ensure that this is the drug of choice for this patient. Ensure that patient receives full course of aminoglycosides as prescribed, divided around the clock to increase effectiveness and decrease the risk for development ..., Cost and benefit considerations G-CSF is an expensive drug. The cost of G-CSF (filgrastim) for the recommended minimum 10-day schedule for prevention of febrile neutropenia after cancer chemotherapy is A$1504 or $2407 per cycle depending on which of the two vial sizes (300 and 480 micrograms/vial) is used., What are the Indications for FILGRASTIM? 1 INDICATIONS AND USAGE RELEUKO is a leukocyte growth factor indicated to: Decrease the incidence of infection‚Äö as manifested by febrile neutropenia‚Äö in patients with nonmyeloid malignancies receiving myelosuppressive anti- cancer drugs associated with a significant incidence of severe ... , Intramuscular penicillin G benzathine is indicated in the treatment of infections due to penicillin-G-sensitive microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response., Medicine Matters Sharing successes, challenges and daily happenings in the Department of Medicine Nadia Hansel, MD, MPH, is the interim director of the Department of Medicine in th..., Colony-Stimulating Factors. Erythropoietin. This article familiarizes the practitioner with the clinical nursing implications of the colony stimulating factors that have been approved for use. The process of hematopoiesis is reviewed with a focus on the mechanisms of action for Sargramostim, Filgrastim, and Epoetin Alfa. Each agent is discuss …., Immunostimulants (Interferons, Interleukins) Immunostimulants or immune stimulants are drugs that energize the immune system when it is exhausted from fighting prolonged invasion or when the immune system needs help fighting a specific pathogen or cancer cell. It is one of the classifications of drug class called immunomodulators ..., What Is Zarxio? Zarxio (filgrastim-sndz) is a 175 amino acid human granulocyte colony-stimulating factor (G-CSF) used to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with nonmyeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of severe neutropenia with fever; to reduce the time to neutrophil ..., Filgrastim is a biosynthetic (recombinant DNA origin) hematopoietic agent that principally affects the proliferation and differentiation of neutrophils within the bone marrow and possibly other sites (e.g., spleen). 2. Filgrastim and tbo-filgrastim are structurally and pharmacologically similar drugs that contain a related drug substance., filgrastim (Neupogen) Reduction of infection risk with bone marrow transplantation, severe chronic neutropenia, myelosuppressive chemotherapy. Administration. Do not shake vials or mix with other drugs; each vial for one dose only; do not administer within 24 hours of cytotoxic drugs., Administration of filgrastim will shorten the length of time of neutropenia in patients with cancer whose bone marrow has been suppressed by antineoplastic drugs or in patients following bone marrow or stem cell transplants. ... What are nursing considerations for administering this drug? (Select all that apply.) a. Monitor intravenous site for ..., PhosLo¬Æ is a phosphate binder indicated for the reduction of serum phosphorus in patients with end stage renal disease. ( 1 ) View Our Nursing Pharmacology Course. References: https://open.fda.gov/. Other Pharm Resources. HYDROXYPROGESTERONE CAPROATE (Makena) Nursing Considerations. , Diagnosis of Neutropenia. Along with the signs and symptoms, neutropenia is primarily diagnosed by obtaining a blood sample from the patient. The normal neutrophil count is above 2.0 and less than 7.5. The following are the types of neutropenia: Mild Neutropenia: 1.0- to 2.0. Moderate Neutropenia: 0.5 to 2.0., GRANIX 300 mcg/0.5 mL: Each prefilled syringe contains 300 mcg of tbo-filgrastim in 0.5 mL solution with a blue plunger in: Pack of 1 without a safety needle guard (for patients and caregivers): NDC 63459-910-17. Packs of 5 without a safety needle guard (for patients and caregivers): NDC 63459-910-36., The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient's neutrophil-count. However, more experience with the off-label use of filgrastrim is needed in the pediatric population., kidney problems --swelling, urinating less, feeling tired or short of breath. Common side effects may include: rash, hair loss. This is not a complete list of side effects and others may occur ..., The 2-day margin was based on data from a pivotal filgrastim study. 3 The difference in mean (placebo minus filgrastim) was 2.95 days (two-sided 95% CL, 2.36 to 3.54). On the basis of the assumption of equivalent efficacy between pegfilgrastim and filgrastim and using the lower bound of the aforementioned 95% CL, a 2-day margin was selected., Neupogen ® (filgrastim) is a drug that has been used successfully for cancer patients to stimulate the growth of the white blood cells, making patients less vulnerable to infections, it is expected to help patients who have bone marrow damage from very high doses of radiation in much the same way. A person who has received a very high dose of ..., Nursing Considerations. • May cause seizures, tremors, hypertension, hepatotoxicity, diarrhea, N/V, gingival hyperplasia. • Increases immune suppression with corticosteroids. • Avoid grapefruit juice while taking this medications. • Assess for signs of organ rejection. • Monitor renal panel, liver enzymes. • Take medication as directed., Nursing Interventions Client Education Jamie Heil Filgrastim 32 Colony-stimulating factor increase neutrophil production in bone marrow and enhance the phagocytic and cytotoxic function of existing neutrophils IV-continuous infusion Subcutaneous Filgrastim not administered until at least 24hrs after chemotherapy because antineoplastic drugs and ..., Serious sickle cell crisis has happened in people with sickle cell disorders receiving filgrastim that has sometimes led to death. Call your doctor right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing. Kidney injury (glomerulonephritis). Kidney injury has been seen in patients who received filgrastim products., Nursing Considerations. • May lead to hypokalemia. • May cause abdominal pain and cramps. • Not for use within 1 hour of taking milk product. • Assess for abdominal distention and bowel function. • Instruct patient to drink 1500-2000 mL/day during therapy. • Monitor fluid and electrolyte levels., Antineoplastic Agents, Phytogenic. Topotecan. Topotecan (Hycamtin, SmithKline Beecham, Philadelphia, PA) was approved by the U.S. Food and Drug Administration in 1996 for use in relapsed ovarian cancer and in 1999 for platinum-sensitive small-cell lung cancer. Hematologic toxicity has been the predominant side effect associated with its use., cetirizine. phenylephrine. codeine. dextromethorphan. guaifenesin. acetylcysteine. Study with Quizlet and memorize flashcards containing terms like factors VIII and IX, desmopressin, heparin and more., Notes. Immunosuppressants or immune suppressants are usually used in conjunction with corticosteroids to block inflammatory reaction and decrease initial damage to cells in cases of organ transplantation and autoimmune diseases. Immunosuppressants include immunomodulators, T- and B-cell suppressors, interleukin receptor antagonist, and ..., The most reliable, and often the only, sign is fever. Teach patients to monitor their temperature and seek medical attention immediately for temperatures of 100.4º F (38º C) or higher. Neutropenic fever, usually defined as a single temperature greater than 100.4º F and an ANC of less than 500/mm3, is a medical emergency.